Apolo

Atividade

81786 - Avaliação Biofarmacêuticas: estudos de solubilidade e permeabilidade de fármacos.

Período da turma:

09/01/2018 a 09/01/2020

Selecione um horário para exibir no calendário:

Descrição:

Programa:
Biofarmácia: conceitos e definições
Solubilidade de fármacos: conceitos, definições, de avaliação
Permeabilidade de fármacos: conceitos, definições, técnica de avalaição
Sistema de Classificação Biofarmacêutica
Liberação e dissoução de fármacos a partir da forma farmacêutica
Anatomia e fidiologia do trato gastrintestinal
Mecanismos de absorção de fármacos
Barreiras para absorção de fármacos administrados por via oral
Fatores que influenciam a absorção de fármacos administrados por via oral
Transporte de fármacos mediado por carreadores
Carredores de efluxo e de influxo
Farmacocinética do processo de absorção de fármacos

Bibliografia:
Abrahamsson, B., Lennernäs, H. Application of the biopharmaceutics classification system now and in the future. Methods Princ. Med. Chem. 18:495-531, 2003.
Amidon, G.L., Lennernäs, H., Shah, V.P., Crison, J.R. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 12(3): 413-420, 1995.
Apparaju, S.K. e Nallani, S.C. Pharmacokinetics: basics of drug absorption from a biopharmaceutical perspective. In: Chilukuri, D.M., Sunkara, G., Young, D. Pharmaceutical product development. In vitro-in vivo correlation. p. 29-46. Informa Healthcare USA, Inc. New York, 2007.
Balimane, P.V. e Chong, S. Cell culture-based models for intestinal permeability: a critique. Drug Discov. Today 10:335-343, 2005.
Balimane, P.V., Han, Y., Chong, S. Current industrial practices of assessing permeability and p-glycoprotein interaction. AAPS J. 8:E1-E13, 2006.
Buckley, S.T., Fischer, S.M., Fricker, G., Brandl, M. In vitro models to evaluate the permeability of poorly soluble drug entities: challenges and perspectives. Eur. J. Pharm. Sci. 45:235-250, 2012.
Cao, X., Gibbs, S.T., Fang, L., Miller, H.A., Landowski, C.P., Shin, H.-C., Lennernäs, H., Zhong, Y., Amidon, G.L., Yu, L.X., Sun, D. Why is challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharm. Res. 23:1675-1686, 2006.
Dahan, A. e Amidon, G.L. Segmental dependent transport of low permeability compounds along the small intestine due to P-Glycoprotein: the role of efflux transport in the oral absorption of BCS Class III drugs. Mol. Pharm. 6:19-28, 2009.
Dahan, A., West, B.T., Amidon, G.L. Segmental-dependent membrane permeability along the intestine following oral drug administration: evaluation of a triple single-pass intestinal perfusion (TSPIP) approach in the rat. Eur. J. Pharm. Sci. 36:320-329, 2009.
Estudante, M., Morais, J.G., Soveral G., Benet, L.Z. Intestinal drug transporters: An overview. Advanced Drug Delivery Reviews. 65:1340–1356, 2013.
Goole, J., Lindley, D.J., Roth, W., Carl, S.M., Amighi, K., Kauffmann, J.M., Knipp, G.T. The effects of excipients on transporter mediated absorption. Int. J. Pharm. 393:17-31, 2010.
Grassi, M., Grassi, G., Lapasin, R., Colombo, I. Gastrointestinal tract. In: Understanding drug release and absorption mechanisms: a physical and mathematical approach, p.29-52. CRC Press, 2007.
Lennernäs, H. Animal data: the contributions of the Ussing chamber and perfusion systems to predicting human oral drug delivery in vivo. Adv. Drug Deliver. Rev. 59:1103-1120, 2007.
Liao, Z.G., Liang, X.L., Zhu, J.Y., Zhao, G.W., Guan, Y.M., Cao, Y.C., Zhao, L.J. Transport properties of puerarin and effect of extract of radix angelicae dahuricae on puerarin intestinal absorption using in situ and in vitro models. Phytother. Res. 28:1288–1294, 2014.
Ramírez-Rigo, M.V., Olivera, M.E., Rubio, M., Manzo, R.H. Enhanced intestinal permeability and oral bioavailability of enalapril maleate upon complexation with the cationic polymethacrylate Eudragit E100. European Journal of Pharmaceutical Sciences. 55:1–11, 2014.
Salana, N.N., Eddington, N.D., Fasano, A. Tight junction modulation and its relationship to drug delivery. Adv. Drug Del. Rev., 58:15-28, 2006.
Sjöstedt, N., Kortejärvi, H., Kidron, H., Vellonen, K.S., Urtti, A., Yliperttula, M. Challenges of Using In vitro Data for Modeling P-Glycoprotein Efflux in the Blood-Brain Barrier. Pharm Res, 31:1–19, 2014. Takano, M., Yumoto, R., Murakami, T. Expression and function of efflux drug transporters in the intestine. Pharmacol. Therapeut. 109:137–161, 2006.
Volpe, D.A. Application of method suitability for drug permeability classification. AAPS J. 12: 670-678, 2010.

Carga Horária:

960 horas

Tipo:

Obrigatória

Vagas oferecidas:

Ministrantes:

Valentina Porta

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